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Abnormal liver tests in patients hospitalized with Coronavirus disease 2019: Should we worry?

Magdalena Meszaros1,2, Lucy Meunier1, David Morquin3

  • 1Department of Hepatology, Gastroenterology and Liver Transplantation, Montpellier University Hospital, University of Montpellier, Montpellier, France.

Liver International : Official Journal of the International Association for the Study of the Liver
|June 5, 2020
PubMed

Insights

Abnormal liver function is common in hospitalized COVID-19 patients in Europe, affecting nearly 67%. These liver test abnormalities predict worse disease and increased mortality risk.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Internal Medicine

Background:

  • COVID-19 has been associated with liver injury in studies from China.
  • Limited data exist on liver dysfunction in European COVID-19 patients.

Purpose of the Study:

  • To determine the prevalence of abnormal liver function in hospitalized COVID-19 patients in France.
  • To assess the predictive value of abnormal liver tests for disease severity and mortality.

Main Methods:

  • Retrospective cohort study including 234 RT-PCR confirmed COVID-19 patients.
  • Data collected included clinical, biological, and radiological information.
  • Multivariate logistic regression analysis was used to identify predictors of outcomes.

Main Results:

  • Abnormal liver function was observed in 66.6% of patients upon admission.
  • Abnormal liver tests were associated with in-hospital aggravation (OR=4.1) and mortality (OR=3.3).
  • Statistical significance was found for both associations (P=.004 and P=.04, respectively).

Conclusions:

  • A high prevalence of abnormal liver tests exists in European COVID-19 patients.
  • Abnormal liver function on admission is a significant predictor of severe disease course.
  • Liver dysfunction is linked to increased in-hospital mortality in this population.

Keywords:
Coronavirus disease 2019SARS-CoV-2abnormal liver testsin-hospital aggravationin-hospital mortalityprognosis

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