Correlation Analysis between Ocular Surface Parameters with Subjective Symptom Severity in Dry Eye Disease

Area of Science:

• Ophthalmology
• Ocular Surface Disease

Background:

• Dry eye disease is a prevalent condition affecting millions globally.
• Accurate assessment of dry eye symptoms is crucial for effective management.

Purpose of the Study:

• To evaluate clinical symptoms in dry eye patients using the Ocular Surface Disease Index (OSDI).
• To analyze the correlation between OSDI scores and various ocular surface parameters.

Main Methods:

• Retrospective study of 45 dry eye patients.
• Assessment included non-invasive keratography (first break-up time, lipid layer thickness), tear osmolarity, matrix metalloproteinase-9, Schirmer I test, and fluorescein break-up time.
• Patient symptoms were evaluated using OSDI questionnaires.

Main Results:

• Significant negative correlations were found between OSDI and non-invasive keratograph first break-up time (p=0.038) and lipid layer thickness (p=0.005).
• No significant correlations were observed between OSDI and fluorescein break-up time, Schirmer I score, or tear osmolarity.
• OSDI scores did not significantly differ between matrix metalloproteinase-9 positive and negative groups (p=0.768).

Conclusions:

• Non-invasive examinations, specifically non-invasive keratograph break-up time and interferometry for lipid layer thickness, are efficient tools for assessing dry eye symptoms.
• These objective measures show promise in complementing subjective symptom reporting in dry eye patients.