Developmental Outcomes of Children Born with Neonatal Abstinence Syndrome (NAS): A Scoping Review
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Updated: Dec 19, 2025

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Sandra Fucile1, Haley Gallant1, Anjali Patel2
1Department of Pediatrics, Queen's University, Kingston, Ontario, Canada.
Insights
Neonatal Abstinence Syndrome (NAS) can impact child development, affecting cognitive, language, and motor skills. More research is needed to understand these developmental outcomes and improve interventions for affected infants.
Area of Science:
- Developmental Pediatrics
- Neonatal Health
- Child Psychology
Background:
- Neonatal Abstinence Syndrome (NAS) is a growing concern in neonatal care.
- Infants with NAS exhibit a range of withdrawal symptoms impacting their early development.
- Understanding long-term developmental trajectories is crucial for this vulnerable population.
Purpose of the Study:
- To synthesize existing literature on the developmental outcomes of children diagnosed with NAS.
- To identify key developmental domains affected in infants with NAS.
- To highlight gaps in current research regarding NAS and child development.
Main Methods:
- A scoping review methodology was employed, guided by the PRISMA framework.
- A comprehensive literature search was conducted across major scientific databases (CINAHL, MEDLINE, EMBASE, Web of Science, PsycINFO).
- Inclusion criteria focused on studies reporting developmental outcomes in children with NAS, with eight studies ultimately included after full-text screening.
Main Results:
- Children with NAS may experience challenges in cognitive and language development.
- School performance, social interactions, and motor skill development are potential areas of concern.
- Inconsistent findings across studies complicate a definitive understanding of NAS developmental impacts.
Conclusions:
- The developmental outcomes for infants with NAS are not yet firmly established due to conflicting research results.
- Further longitudinal research across diverse age groups is essential.
- Improved understanding will facilitate the development of targeted and effective intervention services for high-risk infants with NAS.
Aims:
The purpose of this scoping review is to provide an overview of developmental outcomes of children diagnosed with neonatal abstinence syndrome (NAS).
Methods:
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework was used to guide this scoping review. A comprehensive search of CINAHL, MEDLINE, EMBASE, Web of Science, and PsycINFO was conducted using search terms related to NAS and developmental areas. Full-text screening was completed for 30 articles, and eight studies were included in this review.
Results:
Cognitive and language development, as well as school performance, social and motor domains, may be areas of concern in children with NAS.
Conclusions:
The developmental outcomes of infants with NAS cannot be firmly determined due to inconsistent results across reviewed studies. Future research investigating development across various ages is required for rending more appropriate intervention services to this high-risk population.
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