Related Experiment Video
Updated: Dec 19, 2025

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
An easy and low-cost method of embedding chiral molecules in metal-organic frameworks for enantioseparation
Xiao-Jing Hu1, Ge Huang2, Shuo Zhang2
1State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, P. R. China. rcao@fjirsm.ac.cn tfliu@fjirsm.ac.cn and University of Chinese Academy of Sciences, Beijing, China.
Abstract:
A facile method, post-synthetic exchange of modulators (PSEm), has been demonstrated here to prepare chiral metal-organic frameworks for enantioseparation. Based on this method, three chiral porous Zr-based metal-organic frameworks have been prepared through exchanging the coordinated modulators on metal clusters of MOFs with commercially available chiral carboxylic acid molecules. In addition, the obtained materials show enantioselectivity toward three different enantiomers, which presents a proof of concept for the design of MOF materials for enantioseparation by an easy and low-cost method.
More Related Videos
07:45Electrophoretic Crystallization of Ultrathin High-performance Metal-organic Framework Membranes
Published on: August 16, 2018
10:27Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides
Published on: July 14, 2015
Related Concept Videos
Extraction: Advanced Methods
Prochirality
Molecules with Multiple Chiral Centers
Chirality at Nitrogen, Phosphorus, and Sulfur
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
Racemic Mixtures and the Resolution of Enantiomers