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Related Experiment Video

Updated: Dec 19, 2025

Isolation of Extracellular Vesicles from Murine Bronchoalveolar Lavage Fluid Using an Ultrafiltration Centrifugation Technique
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The correlation between unexplained infertility and exosomes.

Yıldız Uyar1, Melike Özgül2, Sevtap Gökap2

  • 1Manisa Celal Bayar University Medical Faculty, Manisa, Turkey. yildizuyar86@outlook.com.

Ginekologia Polska
|June 5, 2020
PubMed
Summary

Investigating exosome markers CD63 and CD9 in infertile women revealed that higher CD63 in the proliferative phase indicates poor receptivity. Increased CD9 in the secretory phase suggests potential as a biomarker for endometrial receptivity.

Keywords:
embryo implantationendometriumexosomesfertilityinfertility

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Area of Science:

  • Reproductive biology
  • Cell biology
  • Biochemistry

Background:

  • Endometrial receptivity is crucial for successful embryo implantation and fertility.
  • Exosomes and their specific markers, CD63 and CD9, are implicated in various disease processes.
  • Understanding these markers' role in endometrial receptivity could offer new insights into infertility.

Purpose of the Study:

  • To investigate the expression of exosome markers CD63 and CD9 in the endometrium of women with unexplained infertility.
  • To determine the association between CD63 and CD9 levels and endometrial receptivity.
  • To explore the potential of CD63 and CD9 as biomarkers for infertility.

Main Methods:

  • Prospective study conducted from November 2015 to March 2017.
  • Endometrial samples collected during proliferative and secretory phases from fertile and infertile women.
  • Immunohistochemical analysis of CD63 and CD9 distribution in endometrial tissue.

Main Results:

  • CD63 immunoreactivity was significantly higher in the proliferative phase endometrium of infertile patients compared to fertile controls.
  • CD9 immunoreactivity was rarely detected in the proliferative phase of infertile patients.
  • Increased CD9 immunoreactivity was observed in the secretory phase endometrium of infertile patients.

Conclusions:

  • Elevated CD63 in the proliferative phase may indicate unfavorable endometrial receptivity.
  • Increased CD9 in the secretory phase suggests its potential as a biomarker for assessing endometrial receptivity.
  • CD63 and CD9 are potential molecular markers for evaluating infertility.