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Updated: Dec 19, 2025

UV-Vis Spectroscopic Characterization of Nanomaterials in Aqueous Media
Published on: October 25, 2021
Application of chemometric modelling to UV-Vis spectroscopy: development of simultaneous API and critical excipient
Anamaria Angheluta1, Samd Guizani1, Josselin Saunier1
1Product Supply Innovation, Global Technical Operations Manufacturing Technology & Science, Ferring International Center SA, St-Prex, Switzerland.
Abstract:
By applying Chemometric modelling to UV-Vis spectroscopy, a single Multi-Variate Data Analysis predictive model, for in-line monitoring of two component concentrations in solution formulation, was developed. The purpose of this article is to summarize the experimental development work performed for the UV-Vis analytical method and calibration modelling to determine the content of active pharmaceutical ingredient Carbetocin and the content of one critical excipient (l-methionine) in PABAL® solution for injection 100 µg/mL.
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