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COVID-19 vaccine development and the way forward
Narendra Kumar Arora1, Manoja Kumar Das2
1Executive Director, The INCLEN Trust International, New Delhi, India.
Indian Journal of Public Health
|June 5, 2020
Summary
Global COVID-19 vaccine development is accelerating rapidly, with numerous technologies in early trials. Challenges remain, but a successful vaccine is anticipated within 12-18 months.
Area of Science:
- * Virology and Immunology
- * Vaccine Technology and Development
Background:
- * The COVID-19 pandemic necessitates accelerated vaccine development due to high infection rates and mortality.
- * Existing therapeutic options are limited, increasing the urgency for effective vaccines.
Purpose of the Study:
- * To review the current landscape of COVID-19 vaccine development efforts.
- * To identify challenges and facilitators impacting the rapid advancement of vaccine candidates.
Main Methods:
- * Analysis of global vaccine development initiatives, including preclinical and clinical trial stages.
- * Review of various vaccine technologies and platforms being explored.
- * Identification of scientific, technical, and regulatory hurdles.
Main Results:
- * Over 108 vaccine candidates are in development, with 100 in preclinical and 8 in Phase 1 or 2 trials.
- * New technologies are enabling rapid development, but significant challenges persist.
- * Potential hurdles include incomplete understanding of pathophysiology, immune response targeting, animal models, and prior vaccine successes.
Conclusions:
- * Despite challenges, accelerated vaccine development, supported by political and research efforts, aims for a 12-18 month timeline.
- * A modestly efficacious vaccine may be considered a significant achievement in the current pandemic.
- * Continued research and collaboration are crucial for overcoming developmental obstacles.
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