Malassezia Hepatic Abscess in a Neonate

Area of Science:

• Mycology
• Neonatal Medicine
• Infectious Diseases

Background:

• Malassezia species are fungi that depend on external lipids for growth.
• Neonates receiving intravenous lipid infusions are susceptible to disseminated Malassezia infections.
• Common presentations include fungemia or spread to the lungs and bones.

Observation:

• A neonate developed a presumed Malassezia liver abscess.
• The infection was associated with intravenous lipid infusion.
• A mispositioned umbilical venous catheter was identified as the likely route of administration.

Findings:

• This case suggests Malassezia liver abscess as a potential complication in neonates.
• The umbilical venous catheter may have facilitated direct fungal entry into the liver via lipid infusion.
• The findings expand the spectrum of Malassezia-related neonatal pathology.

Implications:

• Highlights the importance of catheter placement and lipid infusion practices in preventing fungal infections in neonates.
• Suggests considering Malassezia liver abscess in neonates with unexplained liver dysfunction and a history of lipid infusion.
• Underscores the need for vigilance regarding fungal infections in vulnerable neonatal populations.