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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Treatment Resistant Cancers02:56

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Bone Marrow Sampling and Transplants01:22

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: Dec 19, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Radiotherapy for Non-Hodgkin Lymphomas.

Brandon S Imber1, Joachim Yahalom2

  • 1From the Department of Radiation Oncology.

Cancer Journal (Sudbury, Mass.)
|June 5, 2020
PubMed
Summary

Radiotherapy (RT) remains crucial for non-Hodgkin lymphoma (NHL) management, offering powerful treatment for aggressive and indolent types. Despite advancements, RT utilization is declining, prompting a review of its current and future roles.

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Area of Science:

  • Radiation oncology
  • Hematology
  • Oncology

Background:

  • Radiotherapy (RT) is a cornerstone in non-Hodgkin lymphoma (NHL) treatment.
  • Modern RT techniques offer safer and more conformal treatments.
  • Despite evidence, RT utilization in NHL is decreasing.

Purpose of the Study:

  • To review the rationale for RT in common NHL scenarios.
  • To evaluate RT strategies for indolent NHL histologies.
  • To discuss the evolving role of RT in the context of new therapies.

Main Methods:

  • Literature review of RT in aggressive and indolent NHL.
  • Analysis of RT's role in combined modality, consolidation, and salvage settings.
  • Evaluation of RT in the era of cellular therapies.

Main Results:

  • RT is a powerful monotherapy for both aggressive and indolent NHL subtypes.
  • Advancements have improved RT safety and precision.
  • Declining utilization trends are observed despite RT's efficacy.

Conclusions:

  • RT remains essential for specific NHL management scenarios.
  • Its role is evolving with new treatment frontiers like cellular therapies.
  • Further research and strategic application are needed to optimize RT's future in NHL.