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Approaches to Modulate the Chronic Wound Environment Using Localized Nucleic Acid Delivery
Adam G Berger1,2,3, Jonathan J Chou1,3,4, Paula T Hammond1,3,4
1Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Advances in Wound Care
|June 5, 2020
Summary
Therapeutic nucleic acids (TNAs) offer a novel strategy for treating chronic wounds, particularly diabetic ulcers. Advanced delivery systems are being developed to enhance TNA efficacy and promote wound healing.
Area of Science:
- Biomedical Engineering
- Molecular Biology
- Dermatology
Background:
- Chronic wounds, especially diabetic ulcers, remain a significant clinical challenge with limited therapeutic options.
- Decades of research have yielded insights into impaired wound healing but few effective treatments.
Purpose of the Study:
- To review recent advances in therapeutic nucleic acid (TNA) delivery for chronic wound treatment.
- To highlight TNA strategies targeting gene pathways crucial for wound healing, focusing on diabetic ulcers.
Main Methods:
- Review of current literature on TNAs (DNA, RNA) and their delivery systems (nanoparticles, hydrogels).
- Analysis of TNA mechanisms targeting inflammation, proteases, cell motility, angiogenesis, epithelialization, and oxidative stress.
Main Results:
- TNAs can modulate the wound microenvironment towards healing by targeting key gene pathways.
- Various delivery systems, including lipid nanoparticles and hydrogels, show promise for TNA application.
Conclusions:
- Localized TNA delivery presents a promising therapeutic avenue for nonhealing chronic wounds.
- Improving spatial and temporal control of TNA delivery is critical for successful clinical translation.
