Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

6.3K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Orbitrap Collision Cross Section Measurements Enhance Isomer Annotations in Lipidomics.

bioRxiv : the preprint server for biology·2026
Same author

Targeting p53 in Cancer: Functional States, Therapeutic Strategies, and Clinical Progress.

Cancers·2026
Same author

Local delivery of rhBMP-2 affects systemic metabolic response during healing of critically-sized segmental defects in a rat model.

Bone·2026
Same author

Endurance exercise elicits temporal and sexual dimorphic multi-omics remodeling of liver metabolism revealed by MoTrPAC.

Cell reports·2026
Same author

Progesterone induces steroidome and lipidome remodeling in a BRCA-resembling mouse model of high-grade serous ovarian cancer.

Translational oncology·2026
Same author

Impact of patient-reported taxane-induced peripheral neuropathy on dose reductions or worsening quality of life in Black women with breast cancer: Analysis from ECOG-ACRIN EAZ171.

Cancer·2026

Related Experiment Video

Updated: Dec 19, 2025

An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
10:35

An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses

Published on: November 28, 2010

18.7K

In vivo modeling of metastatic human high-grade serous ovarian cancer in mice.

Olga Kim1, Eun Young Park1, David L Klinkebiel2

  • 1Department of Biochemistry and Molecular Biology, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.

Plos Genetics
|June 5, 2020
PubMed
Summary

Researchers developed a new mouse model for high-grade serous ovarian cancer (HGSC) metastasis. This model accurately replicates human HGSC peritoneal spread and associated mortality, aiding in understanding and treating this deadly cancer.

More Related Videos

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis
10:58

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis

Published on: July 18, 2016

11.3K
Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
08:55

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence

Published on: November 2, 2014

12.6K

Related Experiment Videos

Last Updated: Dec 19, 2025

An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
10:35

An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses

Published on: November 28, 2010

18.7K
Quantitation of Intra-peritoneal Ovarian Cancer Metastasis
10:58

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis

Published on: July 18, 2016

11.3K
Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
08:55

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence

Published on: November 2, 2014

12.6K

Area of Science:

  • Oncology
  • Genetics
  • Cancer Biology

Background:

  • Metastasis causes 90% of cancer deaths.
  • Modeling human cancer metastasis in vivo remains a significant challenge.
  • High-grade serous ovarian cancer (HGSC) is the most common and lethal type of ovarian cancer.

Purpose of the Study:

  • To develop a robust mouse model for high-grade serous ovarian cancer (HGSC) metastasis.
  • To create a model that accurately recapitulates the peritoneal spread and mortality seen in human HGSC.
  • To provide a valuable tool for studying HGSC progression and evaluating therapeutic strategies.

Main Methods:

  • Genetic engineering of mice to inactivate Dicer1 and Pten, and introduce mutant p53.
  • Observation and analysis of tumor development, metastasis patterns, and survival rates in engineered mice.
  • Histopathological and molecular/genomic characterization of mouse tumors.

Main Results:

  • Engineered mice developed high-grade serous ovarian cancer (HGSC) with complete penetrance.
  • Tumors originated in the fallopian tube, spread to the ovary, and extensively colonized the peritoneal cavity, causing hemorrhagic ascites and 100% mortality.
  • Mouse HGSCs exhibited phenotypic, histopathological, chromosomal instability, impaired DNA repair, and chemosensitivity features similar to human HGSC.

Conclusions:

  • The developed murine model faithfully recapitulates the clinical, molecular, and genomic features of human HGSC metastasis.
  • This model serves as a valuable preclinical tool for investigating HGSC pathogenesis.
  • The model will facilitate the evaluation of novel therapeutic interventions for metastatic ovarian cancer.