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Updated: Dec 19, 2025

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
Published on: June 13, 2025
Broken sleep predicts hardened blood vessels
Raphael Vallat1, Vyoma D Shah1, Susan Redline2
1Center for Human Sleep Science, Department of Psychology, University of California, Berkeley, California, United States of America.
Abstract:
Why does poor-quality sleep lead to atherosclerosis? In a diverse sample of over 1,600 individuals, we describe a pathway wherein sleep fragmentation raises inflammatory-related white blood cell counts (neutrophils and monocytes), thereby increasing atherosclerosis severity, even when other common risk factors have been accounted for. Improving sleep quality may thus represent one preventive strategy for lowering inflammatory status and thus atherosclerosis risk, reinforcing public health policies focused on sleep health.
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