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Related Experiment Video

Updated: Dec 19, 2025

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Breast Milk Modulates Transgenerational Immune Inheritance.

Jakob Zimmermann1, Andrew J Macpherson1

  • 1Maurice Müller Laboratories (Department for BioMedical Research), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, Murtenstrasse 35, University of Bern, 3008 Bern, Switzerland.

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|June 5, 2020
PubMed
Summary
This summary is machine-generated.

Maternal breast milk, specifically immunoglobulin A, non-genetically regulates ROR-γt+ regulatory T cells (Tregs) after birth. This immunoglobulin A inheritance influences colon inflammation and pathogen clearance by ROR-γt+ Tregs.

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Area of Science:

  • Immunology
  • Microbiology
  • Developmental Biology

Background:

  • ROR-γt+ regulatory T cells (Tregs) in the colon balance inflammation and pathogen defense.
  • The regulatory mechanisms governing ROR-γt+ Treg function remain largely unknown.

Purpose of the Study:

  • To elucidate the non-genetic factors controlling ROR-γt+ Treg set-point and function.
  • To understand the maternal contribution to immune system development in neonates.

Main Methods:

  • Investigated the role of maternal factors in ROR-γt+ Treg development.
  • Utilized immunoglobulin A (IgA) as a key focus for maternal inheritance studies.
  • Examined critical time windows for immune programming post-birth.

Main Results:

  • Identified non-genetic maternal inheritance as a critical factor for ROR-γt+ Treg set-point.
  • Demonstrated that immunoglobulin A in breast milk mediates this inheritance.
  • Established a critical window after birth for this immune programming via maternal IgA.

Conclusions:

  • Maternal immunoglobulin A transmitted through breast milk is essential for programming ROR-γt+ Tregs.
  • This maternal transfer influences the colon's immune homeostasis, affecting inflammation and pathogen clearance.
  • Understanding this mechanism offers insights into early-life immune development and potential interventions.