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Effects of a synbiotic on symptoms, and daily functioning in attention deficit hyperactivity disorder - A

Elin Skott1, Liu L Yang2, Miranda Stiernborg2

  • 1Karolinska Institutet, Department of Molecular Medicine and Surgery, Stockholm, Sweden; Karolinska University Hospital Solna, Center for Molecular Medicine, Stockholm, Sweden; PRIMA Child and Adult Psychiatry, Stockholm, Sweden.

Brain, Behavior, and Immunity
|June 5, 2020
PubMed

Insights

Synbiotic 2000 did not significantly improve attention deficit hyperactivity disorder (ADHD) symptoms or overall functioning compared to placebo. However, it showed potential benefits for specific autism symptoms in children and emotion regulation in adults with ADHD, particularly those with elevated sVCAM-1 levels.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Gastroenterology

Background:

  • Prebiotics and probiotics are explored for psychiatric symptom improvement.
  • Limited placebo-controlled studies exist, with no research on attention deficit hyperactivity disorder (ADHD).

Purpose of the Study:

  • To investigate the effects of Synbiotic 2000 on psychiatric symptoms and functioning in children and adults with ADHD.
  • To assess impacts on ADHD symptoms, autism symptoms, daily functioning, and emotion regulation.

Main Methods:

  • A nine-week randomized, double-blind, placebo-controlled trial involving 182 participants with ADHD.
  • Utilized questionnaires (SNAP-IV, ASRS, WFIRS, SCQ, AQ, DERS-16) for symptom assessment.
  • Measured baseline plasma C-reactive protein and soluble vascular cell adhesion molecule-1 (sVCAM-1).

Main Results:

  • Synbiotic 2000 and placebo demonstrated equal improvement in ADHD symptoms.
  • No significant effects on overall functioning or sub-diagnostic autism symptoms were observed for either group.
  • Synbiotic 2000 specifically reduced repetitive behaviors in children and improved goal-directed emotion regulation in adults.
  • In children with elevated sVCAM-1, Synbiotic 2000 reduced autism symptoms, particularly repetitive behaviors.
  • In adults with elevated sVCAM-1, Synbiotic 2000 improved emotion regulation.

Conclusions:

  • No definitive Synbiotic 2000-specific effects were detected overall.
  • Subgroup analyses suggest potential benefits for specific autism symptoms in children and emotion regulation in adults with ADHD, especially those with elevated sVCAM-1.
  • Further research is warranted to explore these targeted effects.

Keywords:
AutismEmotion reactivityInflammationLactic acid bacteriaLactobacillusPrebioticsProbioticsRepetitive behaviorVascular cell adhesion molecule-1

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