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Updated: Dec 19, 2025

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Published on: May 30, 2025
Study protocol: Using peer support to aid in prevention and treatment in prediabetes (UPSTART)
Michele Heisler1, Jeffrey Kullgren2, Caroline Richardson3
1Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, United States of America; VA Center for Clinical Management Research, VA Ann Arbor Healthcare System, Ann Arbor, MI, United States of America.
Insights
Peer support may help individuals with prediabetes make healthy lifestyle changes to prevent type 2 diabetes mellitus (T2DM). This randomized trial will assess the effectiveness of peer coaching versus usual care.
Area of Science:
- Diabetes prevention research
- Behavioral science in health
Background:
- Type 2 diabetes mellitus (T2DM) prevention requires effective and scalable interventions.
- Engagement in healthy lifestyle changes is often low, particularly among minority and low-income populations.
- Prediabetes increases the risk of developing T2DM.
Purpose of the Study:
- To evaluate the effectiveness of a peer support intervention in preventing or delaying T2DM onset.
- To compare a peer support arm with enhanced usual care in a pragmatic trial.
Main Methods:
- A randomized controlled pragmatic trial involving 296 adults with prediabetes.
- Participants were randomized to either a peer support group or enhanced usual care.
- The peer support intervention included initial face-to-face meetings and ongoing weekly/monthly calls from a trained peer coach.
- Outcomes assessed included changes in A1c, weight, and waist circumference.
Main Results:
- Enrollment of at least 296 participants and approximately 75 peer supporters.
- The study is designed to assess changes in key health indicators and patient-centered outcomes.
Conclusions:
- Peer coaching offers a potential strategy to improve adherence to healthy behaviors for T2DM risk reduction.
- Ongoing support from peer coaches may facilitate sustained behavior change in individuals at risk for T2DM.
Background:
There is an urgent need to develop and evaluate effective and scalable interventions to prevent or delay the onset of type 2 diabetes mellitus (T2DM).
Methods:
In this randomized controlled pragmatic trial, 296 adults with prediabetes will be randomized to either a peer support arm or enhanced usual care. Participants in the peer support arm meet face-to-face initially with a trained peer coach who also is a patient at the same health center to receive information on locally available wellness and diabetes prevention programs, discuss behavioral goals related to diabetes prevention, and develop an action plan for the next week to meet their goals. Over six months, peer coaches call their assigned participants weekly to provide support for weekly action steps. In the final 6 months, coaches call participants at least once monthly. Participants in the enhanced usual care arm receive information on local resources and periodic updates on available diabetes prevention programs and resources. Changes in A1c, weight, waist circumference and other patient-centered outcomes and mediators and moderators of intervention effects will be assessed.
Results:
At least 296 participants and approximately 75 peer supporters will be enrolled.
Discussion:
Despite evidence that healthy lifestyle interventions can improve health behaviors and reduce risk for T2DM, engagement in recommended behavior change is low. This is especially true among racial and ethnic minority and low-income adults. Regular outreach and ongoing support from a peer coach may help participants to initiate and sustain healthy behavior changes to reduce their risk of diabetes.
Trial Registration:
The ClinicalTrials.gov registration number is NCT03689530.
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