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Diagnostic accuracy of CE Chirp.
Leigh Biagio-de Jager1, Zandri van Dyk1, Bart Hme Vinck2
1Department of Speech-Language Pathology and Audiology, Faculty of Humanities, University of Pretoria, Hatfield, 0028, South Africa.
Summary
The LS CE-Chirp auditory brainstem response (ABR) shows diagnostic accuracy equivalent to or better than the click-evoked ABR for identifying sensorineural hearing loss in infants. This finding supports its use in neonatal hearing screening protocols.
Area of Science:
- Audiology and Hearing Science
- Neuroscience
- Medical Diagnostics
Background:
- Increasing use of CE-Chirp stimulus in automated auditory brainstem response (AABR) for neonatal hearing screening.
- Need to evaluate the efficacy of newer stimuli compared to established ones.
Purpose of the Study:
- To compare the diagnostic accuracy of LS CE-Chirp-evoked auditory brainstem response (ABR) with click-evoked ABR.
- To assess the identification of various degrees and configurations of sensorineural hearing loss (SNHL).
Main Methods:
- Assessed 49 ears with mild to moderate SNHL (rising and sloping high-frequency types).
- Measured ABR thresholds using both click and LS CE-Chirp stimuli.
- Compared ABR thresholds with behavioral pure tone thresholds (PTA, HFA, LFA) and analyzed diagnostic accuracy using ROC curves.
Main Results:
- LS CE-Chirp ABR showed strong positive correlations with behavioral PTA (r=0.825) and closer proximity to low/mid-frequency thresholds.
- Diagnostic accuracy (AUC) for LS CE-Chirp was equal to or better than click for low (0.83), mid (0.89), and high (0.73) frequencies.
- Click-evoked ABR thresholds were closer to high-frequency averages; both methods had identical sensitivity, specificity, and false negative rates.
Conclusions:
- The LS CE-Chirp-evoked ABR demonstrates diagnostic accuracy comparable or superior to the click-evoked ABR.
- Emphasizes the importance of continuous surveillance and evaluating ABR screening protocols.
