Depressive symptoms effect subjective sleep quality in Chinese patients with Parkinson's disease

The objective of this paper was aimed to estimate the influence of depressive symptoms on subjective sleep quality in Chinese PD patients.

A sample of 491 PD patients was collected and studied in the present study. Depressive symptoms were assessed using the Hamilton Rating Scale for Depression (HAMD). PD severity was assessed using Hoehn and Yahr (H-Y) staging, and motor symptoms were measured with the Unified PD Rating Scale (UPDRS) part III. The Montreal Cognitive Assessment (MOCA) was used to evaluate the global Cognitive status and PD Sleep Scale (PDSS) was used to quantify sleep quality. Three linear regression models were built to check factors associated with caregiver burden, one for the total sample and two for subgroups stratified by the presence of cognitive disturbance.

In our sample, 29.9% of patients suffer from sleep disturbance. The most frequent depressive symptoms were helplessness (81.5%), depressed mood (57.8%), and general somatic symptoms (55.4%) for entire sample. Patients with cognitive disturbance (n = 274; 55.8% of sample) presented more depressive symptoms than patients without cognitive disturbance. Patients suffer poorer sleep quality when patients experience depression with cognitive disturbance. On linear regression models, the main determinants of subjective quality for the total sample were NMS-depression/anxiety/anhedonia, HAMD-anxiety/somatization, disease severity, age and HAMD-loss of weight. For patients with cognitive disturbance, the significant determinants were NMS-depression/anxiety/anhedonia, HAMD-anxiety/somatization, motor symptoms, HAMD-loss of weight and gender. For patients without cognitive disturbance, the significant determinants were NMS-depression/anxiety/anhedonia, disease severity and HAMD-anxiety/somatization.

Depressive symptoms in PD are highly associated with and are determinants of subjective sleep quality, and are more prevalent in patients with cognitive disturbance. Detailed assessment and specific interventions aimed at depression and dementia could alleviate sleep disorder.