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Difensil Immuno Reduces Recurrence and Severity of Tonsillitis in Children: A Randomized Controlled Trial
Arianna Di Stadio1, Antonio Della Volpe2, Fiammetta M Korsch2
1Department of Otolaryngology, University of Perugia, 06129 Perugia, Italy.
Insights
Difensil Immuno (DI) oral supplements reduced tonsillitis and fever recurrence in children. Treatment with DI led to fewer episodes and smaller tonsils, showing its effectiveness in immune support.
Area of Science:
- Pediatrics
- Immunology
- Pharmacology
Background:
- Recurrent tonsillitis and fever are common in children.
- Oral supplements can support the immune system against upper airway infections.
Purpose of the Study:
- To evaluate the efficacy of Difensil Immuno (DI) in reducing tonsillitis and fever recurrence in children.
- To assess the impact of DI on tonsillar volume and clinical outcomes.
Main Methods:
- A multicentric randomized clinical trial involving 120 children with chronic tonsillitis.
- Children were assigned to receive DI (10 mL for 90 days or 15 mL for 45 days) or a control.
- Data collected included tonsillitis/fever episodes, tonsillar volume, and blood tests at baseline, T1, and T2.
Main Results:
- Both DI treatment groups showed statistically significant improvements in clinical parameters (tonsillitis, fever, tonsillar volume) compared to the control group.
- Group A (10 mL for 90 days) exhibited more consistent variances at T1.
- No significant changes were observed in blood parameters across all groups.
Conclusions:
- Difensil Immuno (DI) effectively reduces the recurrence of tonsillitis and fever in children.
- DI treatment leads to a reduction in tonsillar volume.
- Oral supplementation with DI supports immune function in pediatric patients with chronic tonsillitis.
Abstract:
Oral supplements (OS) support the immune system in fighting upper airways infection. This study aimed to analyze the effect of Difensil Immuno (DI) on the recurrence of tonsillitis and fever in children. A multicentric randomized clinical trial was conducted. One-hundred and twenty children with chronic tonsillitis were randomly assigned to group A, B or control. Patients in group A were treated with 10 mL of DI for 90 consecutive days, patients in group B underwent treatment with 15 mL of DI for 45 consecutive days. The following data were collected at baseline (T0), T1 and T2: tonsillitis and fever episodes, tonsillar volume, blood test results. One-way ANOVA was used to analyze within and between variances. Patients in group A and B statistically improved their clinical parameters (episode of tonsillitis and fever, tonsillar volume) when compared to control group both at T1 and T2. However, T1 variances were more consistent in group A than in group B. All patients in the study groups improved their clinical outcomes. No statistically significant variances were observed in blood parameters both at T1 and T2. Our results suggest that children treated with DI had fewer episodes of tonsillitis and fever and a reduction in their tonsillar volume.
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