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Bronchial provocation tests before and after cessation of smoking
R H Israel1, D J Ossip-Klein, R H Poe
1Department of Medicine, Highland Hospital.
Respiration; International Review of Thoracic Diseases
|January 1, 1988
Summary
Smoking cessation resolved chronic cough within two months. However, airway reactivity in smokers remained unchanged after six months of quitting, indicating persistent underlying changes.
Area of Science:
- Pulmonology
- Respiratory Medicine
- Clinical Research
Background:
- Chronic cough is a common symptom in smokers.
- Airway hyperresponsiveness is a hallmark of asthma and can be exacerbated by smoking.
- Understanding the impact of smoking cessation on airway reactivity is crucial for respiratory health.
Purpose of the Study:
- To investigate the effects of smoking cessation on airway reactivity.
- To determine if sustained smoking abstinence improves airway function.
- To assess the resolution of chronic cough in smokers who quit.
Main Methods:
- Recruited smokers with chronic cough (≥10 cigarettes/day).
- Assessed airway reactivity using carbachol challenge tests (measuring PD35 and PD20).
- Measured spirometry (FEV1, SGaw) at baseline, 2 months, and 6 months post-cessation.
Main Results:
- Complete resolution of chronic cough was observed in all 13 subjects who remained abstinent for 6 months.
- No significant changes in airway reactivity (PD35, PD20) were found at 2 or 6 months compared to baseline.
- Relapse rates were high, with 21 out of 34 subjects relapsing before 6 months.
Conclusions:
- Smoking cessation effectively resolves chronic cough in smokers within two months.
- Sustained smoking abstinence for up to six months does not significantly alter airway reactivity.
- Further research may be needed to explore long-term effects or interventions for persistent airway changes.