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Clinical effectiveness of matrine sitz bath in treating perianal infection after chemotherapy for acute leukemia

Ye Zhou1, Huaqiang Gao1, Haiying Hua1

  • 1Department of Hematology, Affiliated Hospital of Jiangnan University, Wuxi 214041, China.

Annals of Palliative Medicine
|June 6, 2020
PubMed
Abstract

Insights

Matrine sitz bath (MSB) effectively treats perianal infections in acute leukemia patients undergoing chemotherapy. This treatment significantly improves symptoms and reduces inflammation compared to conventional methods.

Area of Science:

  • Oncology
  • Infectious Diseases
  • Pharmacology

Background:

  • Perianal infection is a frequent complication in acute leukemia patients during chemotherapy.
  • Symptoms include perianal masses, pain, redness, swelling, and heat, impacting patient well-being.
  • Investigating novel treatments for chemotherapy-induced perianal infections is crucial.

Purpose of the Study:

  • To evaluate the efficacy of matrine sitz bath (MSB) for treating perianal infections in acute leukemia patients post-chemotherapy.
  • To compare MSB treatment with conventional potassium permanganate sitz baths.

Main Methods:

  • A randomized controlled trial involving 216 acute leukemia patients with perianal infection.
  • Patients were assigned to either MSB or conventional potassium permanganate sitz bath groups for 14 days.
  • Clinical efficacy, symptom/sign scores, and serum inflammatory markers (hs-CRP, TNF-α, IL-10, ESR, PGE2) were assessed using ELISA.

Main Results:

  • MSB demonstrated significantly superior clinical efficacy compared to the control group (P<0.05).
  • Both groups showed reduced scores for anal pain, systemic symptoms, and mass characteristics, with greater improvement in the MSB group.
  • MSB treatment led to significant reductions in hs-CRP, TNF-α, ESR, and PGE2, and a significant increase in IL-10 compared to the control group.

Conclusions:

  • Matrine sitz bath (MSB) is an effective treatment for perianal infections in acute leukemia patients receiving chemotherapy.
  • MSB significantly improves clinical symptoms and signs of perianal infection.
  • MSB effectively alleviates inflammatory reactions associated with chemotherapy-induced perianal infections.
Keywords:
Matrineacute leukemiaperianal infectionsitz bath

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