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How to read a published clinical trial: A practical guide for clinicians

Mohamad B Sonbol1, Belal M Firwana2, Talal Hilal3

  • 1Mayo Clinic Cancer Center, Phoenix, Arizona, USA.

Avicenna Journal of Medicine
|June 6, 2020
PubMed

Insights

Healthcare providers must critically appraise clinical trials to integrate new oncology drug approvals into practice. This guide simplifies trial evaluation for clinicians, enhancing patient care through evidence-based medicine.

Area of Science:

  • Oncology
  • Clinical Trials
  • Evidence-Based Medicine

Background:

  • Over 140 new oncology drugs approved in 5 years based on clinical trials.
  • These approvals are transforming clinical practice and patient treatment options.

Purpose of the Study:

  • To provide a simplified approach for healthcare providers to appraise clinical trials.
  • To enable clinicians to determine trial validity, understand results, and apply them to patient care.

Main Methods:

  • A simplified guide for clinicians and trainees on appraising clinical trials.
  • Focus on core concepts and principles applicable across medical specialties.

Main Results:

  • Clinicians can better evaluate the validity and applicability of clinical trial data.
  • Improved understanding of trial results facilitates evidence-based decision-making.

Conclusions:

  • Effective appraisal of clinical trials is crucial for integrating new therapies.
  • This guide equips healthcare professionals with essential skills for modern medical practice.
Keywords:
Apixabanapixaban for the prevention of venous thromboembolismcritical appraisalevidence-based medicineevidence-based practicerandomized-clinical trials

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