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Published on: December 28, 2017
Genetic Heterogeneity of Australian Candida auris Isolates: Insights From a Nonoutbreak Setting Using Whole-Genome
Chayanika Biswas1,2, Qinning Wang1,2, Sebastiaan J van Hal3
1Centre for Infectious Diseases and Microbiology - Public Health, Westmead Hospital, The University of Sydney, Sydney, Australia.
Abstract:
Whole-genome sequencing clustered Australian Candida auris isolates from sporadic cases within clade III. Case isolates were genomically distinct; however, unexpectedly, those from 1 case comprised 2 groups separated by >60 single nucleotide polymorphisms (SNPs) with no isolate being identical, in contrast to outbreaks where isolates from any 1 individual have differed by <3 SNPs. Multidrug resistance was absent. High within-host genetic heterogeneity should be considered when investigating C. auris infections.

