Genomic polymorphism in North-western Indian population based on autosomal STR's: a population data study

Area of Science:

• Population genetics
• Forensic science
• Human genetics

Background:

• Understanding genetic diversity is crucial for population studies and forensic applications.
• Autosomal short tandem repeat (STR) loci are widely used genetic markers.

Purpose of the Study:

• To evaluate genetic diversity and forensic parameters of 20 autosomal STR loci in a North-Western Indian population.
• To assess the suitability of these STR loci for population genetics and forensic identification.

Main Methods:

• Analysis of 243 alleles across 20 autosomal STR loci in 541 unrelated individuals.
• Calculation of genetic diversity indices and forensic parameters (e.g., power of discrimination).
• Comparative analysis of genetic relationships with other Indian and global populations.

Main Results:

• An average of 12.15 alleles per locus was observed, with Penta E being the most polymorphic locus.
• High combined power of exclusion (0.999999998) and discrimination (1) were achieved.
• The studied population demonstrated genetic affinity with geographically proximate populations in India.

Conclusions:

• The selected panel of 20 autosomal STR loci is highly informative and suitable for population genetic studies.
• These STR loci provide robust discriminatory power for forensic applications in the studied population.
• The findings contribute to the understanding of genetic variation within Indian populations.