Related Experiment Video

Updated: Dec 19, 2025

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
09:02

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

22.2K

The Evolution of Targeted Therapies in Chronic Lymphocytic Leukaemia

Valentina Gianfelici1, Luciano Levato1, Stefano Molica2

  • 1Department Hematology-Oncology, Azienda Ospedaliera Pugliese-Ciaccio, 88100, Catanzaro, Italy.

Current Hematologic Malignancy Reports
|June 6, 2020
PubMed
Abstract

Insights

Targeted therapies are transforming chronic lymphocytic leukemia (CLL) treatment. Future strategies focus on minimal residual disease (MRD) to balance efficacy and reduce toxicity, enabling treatment-free remission.

Area of Science:

  • Hematology
  • Oncology
  • Pharmacology

Background:

  • The treatment landscape for chronic lymphocytic leukemia (CLL) is rapidly evolving.
  • Several targeted agents have been recently approved, significantly altering the disease's natural history.

Purpose of the Study:

  • To summarize the evolution of targeted therapies in CLL.
  • To discuss the challenge of balancing treatment efficacy with toxicity in the era of novel agents.
  • To highlight the emerging role of minimal residual disease (MRD) directed therapy.

Main Methods:

  • Review of recent clinical trials and approved targeted therapies for CLL.
  • Analysis of treatment algorithms incorporating MRD assessment.
  • Discussion of fixed-duration treatment strategies based on MRD response.

Main Results:

  • Targeted agents have dramatically improved outcomes in CLL.
  • New treatment algorithms are being developed to personalize therapy.
  • MRD-directed, fixed-duration therapy is emerging as a future standard, aiming for treatment-free remission.

Conclusions:

  • The future of CLL treatment involves tailored strategies balancing efficacy and tolerance.
  • MRD-guided, fixed-duration therapy represents a significant shift towards optimizing patient outcomes and quality of life.
Keywords:
B cell receptor inhibitorsChronic lymphocytic leukaemiaCombination strategiesIndefinite treatmentTime-fixed therapyVenetoclax

More Related Videos

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy06:51

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

15.7K
Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography09:34

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

3.7K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.5K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.6K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.6K