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Updated: Dec 19, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Transition Metal-Catalysed Direct C-H Bond Functionalizations of 2-Pyridone Beyond C3-Selectivity
Aniruddha Biswas1, Saurabh Maity1,2, Subarna Pan1
1Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, 721302, West Bengal, India.
Abstract:
2-Pyridone is a ubiquitous motif in natural products, drug molecules, ligands in catalysis and organic materials. There is a necessity of direct step-economic methods for the construction of 2-pyridone based molecules. Strategically, the primary developments have led to the C3-functionalizations due to the inherent reactivity of this center. Despite this, many elegant transition metal-catalysed methods have been established to introduce versatile functional groups at the C4, C5 and C6-position via direct C-H bond functionalizations. This minireview focuses on the categorized introduction of different functional groups at the 2-pyridone scaffolds beyond C3-selectivity and discusses substrate scope, limitations and plausible mechanistic details.
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