Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...

Exercise Stress Test

Exercise Stress Test

Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes

Heart Failure II: Pathophysiology

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...

Hormonal Regulation

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.

Imbalances in Cardiac Output

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Heart failure endpoints in Food and Drug Administration pivotal trials.

European heart journal·2026

Same author

Let Us Call It Cardiogenic Preshock: A Working Definition From the Heart Failure Collaboratory.

Journal of the American College of Cardiology·2025

Same author

Legends in Cardiology: Giant Sense of Humor.

The American journal of cardiology·2025

Same author

Cardiac Adverse Events in Patients Receiving Immune Checkpoint Inhibitors in the Adjuvant Setting: An FDA Pooled Analysis.

Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·2025

Same author

Myocardial mechanics and cardiac biomarkers in adults with severe anorexia nervosa.

Journal of echocardiography·2023

Same author

Reply: Loperamide-Associated Ventricular Arrhythmias.

Journal of the American College of Cardiology·2023

Search research articles

Related Experiment Video

Updated: Dec 19, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

Subendocardial stress in pre-eclampsia.

Tomio Tran¹, Morteza Farasat^1,2, Mori J Krantz^1,2

¹Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.

Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc

|June 6, 2020

Summary

This summary is machine-generated.

A rare case of peripartum acute myocardial infarction occurred in a woman with pre-eclampsia and malignant hypertension. This condition, characterized by left ventricular hypertrophy, highlights a critical intersection of cardiovascular and obstetric emergencies.

Keywords:

basal septal bulge left ventricular outflow obstruction myocardial infarction pre-eclampsia pregnancy subendocardial ischemia

More Related Videos

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Published on: April 18, 2025

Author Spotlight: A Neonatal Heterotopic Rat Heart Transplantation Model for the Study of Endothelial-to-Mesenchymal Transition

Author Spotlight: A Neonatal Heterotopic Rat Heart Transplantation Model for the Study of Endothelial-to-Mesenchymal Transition

Published on: July 21, 2023

Related Experiment Videos

Last Updated: Dec 19, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Published on: April 18, 2025

Author Spotlight: A Neonatal Heterotopic Rat Heart Transplantation Model for the Study of Endothelial-to-Mesenchymal Transition

Author Spotlight: A Neonatal Heterotopic Rat Heart Transplantation Model for the Study of Endothelial-to-Mesenchymal Transition

Published on: July 21, 2023

Area of Science:

Cardiology
Obstetrics
Maternal-Fetal Medicine

Background:

Peripartum acute myocardial infarction (PAMI) is a rare but serious complication.
Pre-eclampsia with malignant hypertension poses significant cardiovascular risks during pregnancy and postpartum.

Observation:

A 26-year-old primigravida developed pre-eclampsia with malignant hypertension at 30 weeks gestation.
She experienced acute myocardial infarction two days postpartum, presenting with ST-segment depression on ECG.

Findings:

Echocardiography revealed asymmetric left ventricular hypertrophy with a basal septal bulge and a significant mid-cavitary gradient.
Coronary angiography showed normal coronary arteries, ruling out obstructive coronary artery disease.

Implications:

This case underscores the potential for severe cardiac events in the context of hypertensive disorders of pregnancy.
Further research is needed to understand the pathophysiology and optimize management of PAMI associated with pre-eclampsia and left ventricular hypertrophy.