Related Experiment Video
Updated: Dec 19, 2025

Quantification and Whole Genome Characterization of SARS-CoV-2 RNA in Wastewater and Air Samples
Published on: June 30, 2023
Estimating COVID-19 outbreak risk through air travel
Yair Daon1,2, Robin N Thompson3,4, Uri Obolski1,2
1School of Public Health, Tel Aviv University, Tel Aviv, Israel.
Airports in East Asia pose the highest risk for future coronavirus disease 2019 (COVID-19) outbreaks. Understanding travel-related COVID-19 transmission risks is crucial for public health resource allocation.
Area of Science:
- Epidemiology
- Public Health
- Transportation Science
Background:
- Passenger air travel restrictions were implemented to curb severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission.
- As case numbers decline, air travel is expected to resume, posing a risk of imported coronavirus disease 2019 (COVID-19) outbreaks globally.
- This study examines a future scenario with low case numbers and normalized air travel.
Purpose of the Study:
- To estimate the risk of various global locations acting as sources for future coronavirus disease 2019 (COVID-19) outbreaks.
- To identify specific airports with a high potential to seed outbreaks through international travel.
Main Methods:
- Utilized modeled global air travel data and population density estimates for 1364 airports worldwide.
- Employed a probabilistic, branching-process-based approach.
- Incorporated air traveler volume between airports and local reproduction numbers, considering population density.
Main Results:
- Airports in East Asia were identified as having the highest risk of originating future outbreaks.
- India and Brazil face the highest risk of COVID-19 outbreaks seeded by domestic travelers.
- Outbreaks in Africa are most likely to be initiated by international travelers arriving on the continent.
Conclusions:
- The spatial distribution of outbreak risk is non-uniform, influenced by flight volumes and destination population densities.
- Quantifying outbreak risk geographically aids in optimizing resource allocation for public health interventions.
- Targeted public health strategies are essential for mitigating COVID-19 spread via air travel.
Related Concept Videos
Steps in Outbreak Investigation
Causality in Epidemiology
Relative Risk
Principles of Disease Surveillance
Estimating Population Standard Deviation
Transmission-based Precautions II: Airborne and Protective Environment
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...

