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Miller-Fisher syndrome after SARS-CoV-2 infection
J A Reyes-Bueno1, L García-Trujillo1, P Urbaneja1
1Neurology Department, Regional University Hospital of Málaga, Málaga, Spain.
European Journal of Neurology
|June 6, 2020
Summary
This case study reports a rare instance of Miller Fisher Syndrome (MFS) developing two weeks after a COVID-19 infection. This highlights a potential neurological complication of SARS-CoV-2, even with initial negative PCR tests.
Area of Science:
- Neurology
- Infectious Diseases
- Immunology
Background:
- The SARS-CoV-2 pandemic has been associated with various neurological complications, including central and peripheral nervous system involvement.
- Post-infectious neurological syndromes are increasingly recognized as potential sequelae of COVID-19.
Observation:
- A 51-year-old female presented with Miller Fisher Syndrome (MFS) two weeks after a COVID-19 infection.
- Her SARS-CoV-2 reverse transcription polymerase chain reaction (RTPCR) test was negative, but IgG antibodies were positive, indicating a past infection.
Findings:
- This represents the third reported case of MFS associated with COVID-19.
- The patient responded well to intravenous immunoglobulin (IVIg) treatment, a common therapy for MFS.
Implications:
- The findings suggest that MFS may be an underdiagnosed neurological complication of COVID-19, particularly in the subacute phase.
- Further research is needed to understand the pathophysiology and incidence of post-COVID-19 neurological syndromes.
Keywords:
COVID-19Guillain-Barré syndromeMiller-Fisher variantSARS-CoV-2acute inflammatory demyelinating polyneuropathyMore Related Videos
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