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Human Parvoviruses May Affect the Development and Clinical Course of Meningitis and Meningoencephalitis

Anda Vilmane1, Anna Terentjeva1, Paulius L Tamosiunas2

  • 1Institute of Microbiology and Virology, Rīga Stradiņš University, 5 Ratsupites St., LV-1067 Riga, Latvia.

Brain Sciences
|June 7, 2020
PubMed

Insights

Human bocaviruses (HBoV1-4) and parvovirus B19 (B19V) were detected in over half of meningitis patients in Latvia. These viral infections are linked to severe symptoms, suggesting their inclusion in diagnostics for unexplained neurological cases.

Area of Science:

  • Neurology
  • Virology
  • Infectious Diseases

Background:

  • Meningitis and meningoencephalitis are inflammatory neurological conditions often lacking a definitive cause despite broad diagnostic testing.
  • Human parvoviruses, including B19V, HBoV1-4, and hPARV4, are linked to diverse clinical symptoms, including neurological disorders.

Purpose of the Study:

  • To investigate the prevalence of human parvovirus infections in meningitis/meningoencephalitis patients in Latvia.
  • To elucidate the role of these parvoviruses in the clinical presentation and course of meningitis/meningoencephalitis.

Main Methods:

  • Genomic sequencing was employed to detect viral sequences in patient samples.
  • Clinical data, including symptoms like headache, fatigue, disorientation, and concentration difficulties, were analyzed.

Main Results:

  • Human bocaviruses (HBoV1-4) and parvovirus B19 (B19V) genomic sequences were identified in 52.38% and 16.67% of patients, respectively.
  • Patients with active parvovirus infections exhibited significantly higher frequencies of headache, fatigue, disorientation, and concentration difficulties compared to parvovirus-negative patients.

Conclusions:

  • Human bocaviruses (HBoV1-4) and parvovirus B19 (B19V) are significant contributors to meningitis/meningoencephalitis in Latvia.
  • Routine diagnostics for meningitis/meningoencephalitis should incorporate testing for HBoV1-4 and B19V to address cases of unknown etiology.
Keywords:
human bocaviruses 1–4human parvovirus 4human parvovirus B19meningitismeningoencephalitis

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