Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.5K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.5K
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

355
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
355

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Strain-Dependent Differences in Baseline Retinal Immune Homeostasis: A Comparative Study of Albino and Pigmented Mice.

Cellular and molecular neurobiology·2026
Same author

Pre‒pregnancy body mass index and Gestational Diabetes as key determinants of long‒term metabolic risk: insights from a nutritional intervention during pregnancy.

Diabetes research and clinical practice·2026
Same author

Tears as a window to Alzheimer's disease: A systematic review of biomarkers for early detection.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same author

Virtual Reality-Based Dichoptic Therapy in Acquired Brain Injury: Functional and Symptom Outcomes.

Journal of clinical medicine·2026
Same author

Early and progressive retinal microglial changes in APP<sup>NL-F/NL-F</sup> mouse model of Alzheimer's disease revealed by an automated image analysis software.

Frontiers in aging neuroscience·2026
Same author

In Vivo Functional and Structural Retinal Preservation by Combined Administration of Citicoline and Coenzyme Q10 in a Murine Model of Ocular Hypertension.

International journal of molecular sciences·2026
Same journal

Evidence-Based Clinical Recommendations for the Appropriate Use of Diagnostic Tests in Pediatric Allergology: Focus on Asthma, Rhinoconjunctivitis, and Keratoconjunctivitis Vernal.

Journal of clinical medicine·2026
Same journal

Surgical and Transcatheter Approach of a Failed Mitral Valve Repair: A Comprehensive Review on Selecting the Most Suitable Approach.

Journal of clinical medicine·2026
Same journal

Hybrid Metaheuristic Feature Selection for Breast Cancer Detection in Digital Mammography: A Feasibility Study with Nested Validation, Benchmarking, and External Stress Testing.

Journal of clinical medicine·2026
Same journal

Identity Transformation and the Role of Accountability in Recovery from Problematic Pornography Use: A Phenomenological-Hermeneutical Study.

Journal of clinical medicine·2026
Same journal

Does Early Surgical Treatment in Degenerative Cervical Myelopathy Have a Favorable Clinical Outcome and Impact on Quality of Life?

Journal of clinical medicine·2026
Same journal

Shear Wave Elastography in Musculoskeletal Imaging: A Narrative Review.

Journal of clinical medicine·2026
See all related articles

Related Experiment Video

Updated: Dec 19, 2025

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

22.1K

Macular Thickness Decrease in Asymptomatic Subjects at High Genetic Risk of Developing Alzheimer's Disease: An OCT

Inés López-Cuenca1, Rosa de de Hoz1,2,3, Elena Salobrar-García1,2,3

  • 1Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain.

Journal of Clinical Medicine
|June 7, 2020
PubMed
Summary
This summary is machine-generated.

Individuals at high genetic risk for Alzheimer's disease (AD) show early retinal changes in the macula, not the peripapillary region. Optical coherence tomography (OCT) may detect these preclinical signs.

Keywords:
Alzheimer´s diseaseApoE ɛ4OCTfirst-degree family historygenetic riskretina

More Related Videos

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
07:08

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats

Published on: January 10, 2019

10.4K
In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma
12:48

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

Published on: May 11, 2015

11.0K

Related Experiment Videos

Last Updated: Dec 19, 2025

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

22.1K
Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
07:08

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats

Published on: January 10, 2019

10.4K
In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma
12:48

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

Published on: May 11, 2015

11.0K

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Genetics

Background:

  • Alzheimer's disease (AD) poses a significant health challenge, with early detection crucial for intervention.
  • Genetic factors, including family history (FH+) and ApoE ɛ4 allele, increase AD risk.
  • Retinal changes may serve as early biomarkers for neurodegenerative diseases like AD.

Purpose of the Study:

  • To investigate macular and peripapillary retinal thickness in cognitively healthy individuals at high genetic risk for AD.
  • To compare retinal layer measurements between individuals with a family history of AD and ApoE ɛ4 carriage (FH+/ɛ4+) versus controls (FH-/ɛ4-).

Main Methods:

  • Case-control study involving 35 FH+/ɛ4+ subjects and 29 age-matched FH-/ɛ4- controls.
  • Optical coherence tomography (OCT) used to measure retinal thickness in macular layers and peripapillary retinal nerve fiber layer (RNFL).

Main Results:

  • FH+/ɛ4+ carriers showed significant reductions in macular RNFL, inner plexiform layer (IPL), inner nuclear layer (INL), and outer plexiform layer (OPL) compared to controls.
  • No significant differences in peripapillary RNFL thickness were observed between the groups.
  • Early retinal changes associated with AD risk were localized to the macular region.

Conclusions:

  • Cognitively healthy individuals with high genetic risk for AD exhibit initial retinal thinning in specific macular sublayers.
  • OCT is a potential non-invasive tool for early AD detection, preceding clinical symptoms.
  • Macular OCT may offer a cost-effective screening method for preclinical AD.