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Related Concept Videos

Replication in Prokaryotes01:32

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DNA replication has three main steps: initiation, elongation, and termination. Replication in prokaryotes begins when initiator proteins bind to the single origin of replication (ori) on the cell's circular chromosome. Replication then proceeds around the entire circle of the chromosome in each direction from the two replication forks, resulting in two DNA molecules.
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In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
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The Replisome03:01

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DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
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Related Experiment Video

Updated: Dec 19, 2025

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method
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Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method

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Archaeal DNA Replication.

Mark D Greci1, Stephen D Bell1,2

  • 1Department of Biology, Indiana University, Bloomington, Indiana 47405, USA;

Annual Review of Microbiology
|June 7, 2020
PubMed
Summary
This summary is machine-generated.

Archaea

Keywords:
CMGDNA polymeraseDNA primaseSulfolobusarchaeahelicase

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Area of Science:

  • Molecular Biology
  • Genomics
  • Biochemistry

Background:

  • Archaea share information processing machinery with eukaryotes, distinct from bacteria.
  • Archaea exhibit diverse cell cycle organization, chromosome ploidy, and replication mechanisms.

Purpose of the Study:

  • To review recent advances in archaeal DNA replication.
  • To highlight conserved features and lineage-specific innovations in archaeal DNA replication.

Main Methods:

  • Comparative genomics
  • Biochemical assays
  • Structural biology

Main Results:

  • Archaea display significant diversity in DNA replication origins, proteins, and polymerases.
  • Conserved features in DNA replication machinery are observed across archaeal lineages.
  • Lineage-specific innovations drive diversity in archaeal DNA replication.

Conclusions:

  • Understanding archaeal DNA replication provides insights into eukaryotic origins.
  • Archaea serve as a model for studying fundamental DNA replication processes.