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Related Experiment Video

Updated: Dec 19, 2025

Innovative Adipose Tissue Fractionation for Transforming Fat into Specialized Components
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Incorporating Fat Grafting with Facelift Surgery: When, How, and Where.

Edward D Buckingham1, Scott W Smith2

  • 1Facial Plastic and Reconstructive Surgery, Buckingham Center for Facial Plastic Surgery, 2745 Bee Caves Road, Suite 101, Austin, TX 78746, USA.

Facial Plastic Surgery Clinics of North America
|June 7, 2020
PubMed
Summary

Facial aging results from skin changes, gravity, and volume loss. Bone loss and skeletal remodeling are key drivers of facial volume loss, causing hollows and shadows.

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Area of Science:

  • Gerontology
  • Dermatology
  • Plastic Surgery

Background:

  • Facial aging is a complex process influenced by multiple factors over time.
  • Current understanding suggests aging involves skin quality changes, gravitational tissue descent, and volume loss.
  • Bone loss and skeletal remodeling are identified as primary contributors to facial volume reduction.

Purpose of the Study:

  • To explore the multifactorial nature of facial aging.
  • To elucidate the primary causes of facial volume loss.
  • To understand the interplay between skeletal changes and soft tissue alterations in facial aging.

Main Methods:

  • Review of existing literature on facial aging theories.
  • Analysis of studies investigating skin quality, tissue ptosis, and retaining ligaments.
Keywords:
Autologous fat graftingFacial volume lossRhytidectomy

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  • Examination of research on skeletal remodeling and bone density changes in the face.

    • Main Results:

    • Facial aging is multifactorial, involving skin, gravity, and volume loss.
    • Skeletal remodeling and associated bone loss significantly contribute to facial volume loss.
    • Characteristic facial shadows and hollows are linked to bone loss and unelucidated soft tissue changes.

    Conclusions:

    • Facial aging is a composite of intrinsic and extrinsic factors.
    • Bone loss is a critical, yet often underestimated, component of age-related facial volume reduction.
    • Further research is needed to fully understand soft tissue dynamics in facial aging.