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DNA origami-based single-molecule force spectroscopy elucidates RNA Polymerase III pre-initiation complex stability

Kevin Kramm1, Tim Schröder2, Jerome Gouge3

  • 1Single-Molecule Biochemistry Lab, Institute of Microbiology and Archaea Centre, University of Regensburg, 93053, Regensburg, Germany.

Nature Communications
|June 7, 2020
PubMed
Summary

The study reveals how DNA strain affects transcription initiation. Bdp1 is crucial for stabilizing RNA polymerase III (RNAP III) initiation complexes on strained DNA, explaining RNAP III

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