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Published on: October 7, 2021
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Subependymal hyperintense layer on CISS sequence: An MRI study.
Satoshi Tsutsumi1, Hideo Ono2, Hisato Ishii3
1Department of Neurological Surgery, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu, Chiba, 279-0021, Japan. shotaro@juntendo-urayasu.jp.
Summary
Subependymal hyperintensities, visualized with MRI, may indicate fluid pathways between Virchow-Robin spaces and cerebrospinal fluid. This finding aids understanding of interstitial fluid migration in the brain.
Area of Science:
- Neuroimaging
- Neuroanatomy
- Cerebrospinal Fluid Dynamics
Background:
- The subependymal layers of cerebral ventricles play a role in fluid exchange.
- Understanding these layers is crucial for comprehending brain physiology.
Purpose of the Study:
- To investigate the subependymal layers overlying cerebral ventricles using magnetic resonance imaging (MRI).
- To characterize the appearance and potential function of subependymal hyperintensities.
Main Methods:
- Utilized constructive interference in steady-state (CISS) MRI sequences.
- Acquired thin-sliced, coronal, and sagittal images from 69 outpatients.
- Delineated subependymal layers as linear hyperintensities along ventricular walls.
Main Results:
- Subependymal hyperintensities were identified in high percentages of patients across different ventricular regions (anterior horn, third ventricle, trigone, posterior horn).
- Coronal imaging revealed hyperintensities in 96-97% for anterior and third ventricles, and 100% for trigone/posterior horns.
- Sagittal imaging showed hyperintensities in all patients.
- Communication between subependymal hyperintensities and Virchow-Robin spaces (VRSs) was observed in 65-83% of patients, depending on the location.
Conclusions:
- Subependymal hyperintensities likely represent an inflow passage for VRSs.
- These structures may facilitate the transependymal migration of interstitial fluid into the ventricular cerebrospinal fluid.
