Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Energy-Dense High-Fat/High-Sucrose Diet to Induce Type 2 Diabetes Mellitus in BALB/c Mice Without Genetic Modifications and Chemical Agents.

Biology·2026

Same author

Acute lung injury is prevented by monocyte locomotion inhibitory factor in an experimental severe malaria mouse model.

Immunobiology·2024

Same author

Adenosine increases PD-L1 expression in mesenchymal stromal cells derived from cervical cancer through its interaction with A<sub>2A</sub>R/A<sub>2B</sub>R and the production of TGF-β1.

Cell biochemistry and function·2024

Same author

Application of Multiparametric Flow Cytometry Panels to Study Lymphocyte Subpopulations in Tuberculin-Positive Cattle.

Veterinary sciences·2023

Same author

Synthesis, characterization and evaluation of prenylated chalcones ethers as promising antileishmanial compounds.

Molecular diversity·2022

Same author

Mexican Oregano (<i>Lippia berlandieri</i> Schauer and <i>Poliomintha longiflora</i> Gray) Essential Oils Induce Cell Death by Apoptosis in <i>Leishmania (Leishmania) mexicana</i> Promastigotes.

Molecules (Basel, Switzerland)·2022

Search research articles

Related Experiment Video

Updated: Dec 19, 2025

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products

Published on: April 6, 2015

Fasciola hepatica-derived molecules as potential immunomodulators.

Gerardo Manuel Corral-Ruiz¹, Luvia Enid Sánchez-Torres¹

¹Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala, s/n, 11340 Ciudad de México, México.

|June 8, 2020

Summary

Helminths like Fasciola hepatica secrete molecules that modulate immune responses, reducing inflammation. These parasite-derived compounds show potential as novel anti-inflammatory therapies for autoimmune and allergic diseases.

Keywords:

Excretory-secretory molecules Fasciola hepatica Helminth Immunoregulation Inflammation Trematode

More Related Videos

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

Related Experiment Videos

Last Updated: Dec 19, 2025

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products

Published on: April 6, 2015

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

Area of Science:

Parasitology
Immunology
Drug Discovery

Background:

Helminths have co-evolved with hosts, developing mechanisms to evade immune responses.
Fasciola hepatica, a parasitic helminth, secretes molecules that suppress host immunity.
These molecules induce an anti-inflammatory and regulatory immune phenotype.

Purpose of the Study:

To review molecules secreted by Fasciola hepatica and other helminths.
To characterize their anti-inflammatory and immunomodulatory mechanisms.
To explore their therapeutic potential for inflammatory diseases.

Main Methods:

Review of scientific literature on helminth-derived molecules.
Analysis of studies investigating the immunomodulatory effects of helminth products.
Examination of extracellular vesicles and purified molecules from helminths.

Main Results:

Helminth molecules modulate host immune cells, reducing antiparasitic capacity.
Secreted products promote anti-inflammatory and regulatory immune responses.
F. hepatica molecules are particularly effective in immune modulation.

Conclusions:

Helminth-derived molecules offer promising alternatives to current therapies for inflammatory conditions.
Further research into these molecules could lead to new treatments for autoimmunity and allergies.
Fasciola hepatica products warrant continued investigation for their therapeutic potential.