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Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury
Published on: May 21, 2018
Non-coding RNAs and Exosomes: Their Role in the Pathogenesis of Sepsis
Seyed MohammadReza Hashemian1, Mohammad Hossein Pourhanifeh2, Sara Fadaei3
1Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran; Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract:
Sepsis is characterized as an uncontrolled host response to infection, and it represents a serious health challenge, causing excess mortality and morbidity worldwide. The discovery of sepsis-related epigenetic and molecular mechanisms could result in improved diagnostic and therapeutic approaches, leading to a reduced overall risk for affected patients. Accumulating data show that microRNAs, non-coding RNAs, and exosomes could all be considered as novel diagnostic markers for sepsis patients. These biomarkers have been demonstrated to be involved in regulation of sepsis pathophysiology. However, epigenetic modifications have not yet been widely reported in actual clinical settings, and further investigation is required to determine their importance in intensive care patients. Further studies should be carried out to explore tissue-specific or organ-specific epigenetic RNA-based biomarkers and their therapeutic potential in sepsis patients.
Insights
Sepsis, a life-threatening condition, involves uncontrolled infection responses. Exploring microRNAs, non-coding RNAs, and exosomes offers potential for new sepsis diagnostics and treatments.
Area of Science:
- Biochemistry
- Molecular Biology
- Genetics
Background:
- Sepsis is a global health crisis with high mortality and morbidity.
- Uncontrolled host response to infection defines sepsis.
- Current diagnostic and therapeutic strategies for sepsis require improvement.
Purpose of the Study:
- To explore novel epigenetic and molecular mechanisms in sepsis.
- To identify potential diagnostic biomarkers for sepsis.
- To investigate the therapeutic potential of RNA-based biomarkers in sepsis.
Main Methods:
- Review of accumulating data on microRNAs, non-coding RNAs, and exosomes.
- Analysis of their role in regulating sepsis pathophysiology.
- Assessment of current clinical reporting of epigenetic modifications in sepsis.
Main Results:
- MicroRNAs, non-coding RNAs, and exosomes show promise as novel sepsis biomarkers.
- These biomarkers are implicated in the regulation of sepsis pathophysiology.
- Epigenetic modifications are not yet widely utilized in clinical sepsis settings.
Conclusions:
- Epigenetic and molecular discoveries can enhance sepsis diagnostics and therapeutics.
- RNA-based biomarkers like microRNAs, non-coding RNAs, and exosomes warrant further investigation.
- More research is needed on tissue-specific epigenetic biomarkers for clinical application in intensive care patients.
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