Related Experiment Video
Updated: Aug 5, 2026

Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy
Published on: August 14, 2012
Primary hepatic neuroendocrine tumor: A case report and literature review
Adriano C Costa1, Fernando Santa-Cruz2, Henrique Guimarães2
1Oncological Surgery Unit, Napoleão Laureano Hospital, João Pessoa, PB, Brazil; Department of Surgery, Federal University of Pernambuco, Recife, PE, Brazil.
Introduction:
Primary hepatic neuroendocrine tumors (PHNETs) are extremely rare, having less than 200 cases reported in the literature.
Presentation Of Case:
A 51-year-old woman presenting with mild intensity sharp pain in the upper abdomen that started 4 years ago. Preoperative Magnetic Resonance Imaging (MRI) suggested hepatocellular adenoma. Surgical exploration found a tumor occupying the whole segment IV of the liver, therefore a left hepatectomy was performed. Pathology and immunohistochemistry indicated to be a low-grade neuroendocrine tumor of the liver. The patient is enjoying a good quality of life, free of disease, presenting no signs of recurrence nor metastases 12 months after the procedure.
Conclusion:
The clinical presentation of PHNETs is non-specific and its radiologic features are intensely diversified, frequently leading to misdiagnosis of other hepatic neoplasms.

