Effect of Yarcha Gumba (O sinensis) on Male Reproductive System in Rat

The present study was undertaken to assess the aphrodisiac effect of O sinensis. It was a pre-clinical experimental case-control study performed in the Department of Pharmacology, RG Kar Medical College, Kolkata, India; from February 2019 to March 2019 using Wister rat model. One group of rats was given the test drug suspension (10mg/kg body weight) and the control group animals received the same volume of vehicle devoid of drug orally for 10 days. Sexual behaviour of individual rats was studied on 9th day of treatment with oestrogenized female Wister rats. On 10th day of treatment the animals were sacrificed by decapitation. After collection of blood sera from each animal; serum LH, FSH, testosterone and nitric oxide were assessed. Histological assessment of testes was done. Improved sexual behaviour, hypertrophy of Leydig cells, significant increase in serum LH (1.248 vs. 1.448mIU/ml), FSH (0.324 vs. 0.413mIU/ml) testosterone (3.120 vs. 4.498ng/ml) and nitric oxide (0.01757 vs. 0.02690nM/ml) were noted. Elevated NO titre in animals treated with O sinensis extract might be the cause of good erection capacity and increased libido in them. Nevertheless, result of the present study points that the active principle of O sinensis also acts on LHRH receptors present in pituitary gonadotrophs evidenced by significant increase in serum LH and FSH and indicating great aphrodisiac property.