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Phylogenetic Analysis of Clinically Relevant Fusarium Species in Iran

Mohammad Javad Najafzadeh1,2, Somayeh Dolatabadi3, Sybren de Hoog4,5

  • 1Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Mycopathologia
|June 8, 2020
PubMed

Insights

Fusarium fungi cause significant human infections, with the Fusarium fujikuroi species complex being the most common etiological agent. Accurate identification of these fungal pathogens is crucial for effective treatment of fusariosis, particularly nail infections and keratitis.

Area of Science:

  • Medical Mycology
  • Clinical Microbiology
  • Molecular Phylogenetics

Background:

  • Fungi of the genus Fusarium are recognized as significant plant pathogens and opportunistic human pathogens.
  • Clinical manifestations of fusariosis range from superficial infections to life-threatening invasive diseases.

Purpose of the Study:

  • To identify and phylogenetically characterize clinical Fusarium isolates from Iran.
  • To determine the etiological agents responsible for fusariosis in the studied population.

Main Methods:

  • DNA extraction and sequencing of the TEF1 gene for fungal barcoding.
  • Phylogenetic analysis using constructed trees with type strains for accurate species complex identification.
  • Retrospective analysis of clinical data to correlate fungal species with infection types.

Main Results:

  • Sixty-three clinical Fusarium isolates were identified, with the Fusarium fujikuroi species complex (FFSC) being dominant (65%).
  • The Fusarium solani (FSSC, 22%) and Fusarium oxysporum (FOSC, 11%) species complexes were also identified.
  • Nail infections (60.3%) and keratitis (34%) were the most frequent clinical presentations of fusariosis.

Conclusions:

  • This study presents the first phylogenetic analysis of clinical Fusarium species from Iran.
  • The dominance of FFSC highlights its importance as a clinical pathogen in the region.
  • Accurate and rapid identification of Fusarium species is essential for managing infections, given their azole resistance.
Keywords:
Fusarium fujikuroiKeratitisPhylogeny

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