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Updated: Jul 2, 2026

Electron Spin Resonance Micro-imaging of Live Species for Oxygen Mapping
Published on: August 26, 2010
Biological validation of electron paramagnetic resonance (EPR) image oxygen thresholds in tissue
Inna Gertsenshteyn1,2,3, Mihai Giurcanu4, Peter Vaupel5,6
1Department of Radiology, University of Chicago, IL, USA.
Abstract:
Measuring molecular oxygen levels in vivo has been the cornerstone of understanding the effects of hypoxia in normal tissues and malignant tumors. Here we discuss the advances in a variety of partial pressure of oxygen ( ) measurements and imaging techniques and relevant oxygen thresholds. A focus on electron paramagnetic resonance (EPR) imaging shows the validation of treating hypoxic tumours with a threshold of ≤ 10 Torr, and demonstrates utility for in vivo oxygen imaging, as well as its current and future role in cancer studies.

