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Analytical and Bioanalytical Techniques for the Quantification of the Calcium Channel Blocker - Amlodipine: A

K S Kokilambigai1, J Kavitha1, R Seetharaman1

  • 1Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India.

Critical Reviews in Analytical Chemistry
|June 9, 2020
PubMed

Insights

This review details analytical methods for quantifying amlodipine, a popular long-acting dihydropyridine calcium channel blocker used to treat hypertension. It covers techniques for measuring the drug alone and in combination formulations from 1989 to 2019.

Area of Science:

  • Pharmacology
  • Analytical Chemistry
  • Medicinal Chemistry

Background:

  • Hypertension management relies on effective antihypertensive agents.
  • Calcium channel blockers, particularly dihydropyridines (DHPs), are crucial in treating hypertension.
  • Long-acting DHPs like amlodipine offer therapeutic advantages due to improved patient compliance and reduced side effects.

Purpose of the Study:

  • To provide a comprehensive overview of analytical and bioanalytical techniques for amlodipine quantification.
  • To review methods for analyzing amlodipine as a single entity and in pharmaceutical combinations.
  • To cover the period from 1989 to 2019, highlighting advancements in quantification.

Main Methods:

  • Literature review of analytical and bioanalytical methods.
  • Focus on techniques for amlodipine quantification in various matrices.
  • Inclusion of methods for single-drug and combination formulations.

Main Results:

  • A wide array of analytical techniques, including chromatography and spectroscopy, are employed for amlodipine quantification.
  • Established methods exist for both single-drug analysis and its determination in complex pharmaceutical formulations.
  • The period reviewed shows consistent development and refinement of quantification techniques.

Conclusions:

  • Accurate and reliable analytical methods are essential for quality control and therapeutic monitoring of amlodipine.
  • The evolution of analytical techniques has supported the widespread use and efficacy of amlodipine in hypertension management.
  • This review serves as a valuable resource for researchers and practitioners in pharmaceutical analysis.

Keywords:
Amlodipinebioanalytical methodscalcium channel blockerhypertensionpharmaceutical formulationsreview

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