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Molecular Genetics of Intraocular Tumors
Mehenaz Hanbazazh1, Thaddeus P Dryja1
1David G Cogan Laboratory of Ophthalmic Pathology, Massachusetts Eye and Ear Infirmary, Harvard Medical School , Boston, MA, USA.
Purpose:
To explore the value of molecular technologies in the pathologic evaluation, diagnosis, and treatment of retinoblastoma and uveal melanoma.
Methods:
Review of the peer-reviewed literature on the molecular pathology of primary intraocular tumors.
Conclusion:
Molecular tests are playing an increasingly important role in the diagnosis of intraocular tumors. They provide information valuable for diagnosis, prognosis, screening regimens, genetic counselling, and treatment. These technologies are becoming easier, faster, and with higher sensitivity and accuracy.
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