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Cladribine transfer into human milk: A case report
Palika Datta1, Andrea I Ciplea2, Kathleen Rewers-Felkins1
1Department of Pediatrics, Texas Tech University Health Sciences Center, Amarillo, TX, USA.
Background:
Cladribine is an antimetabolite used for the treatment of relapsing-remitting multiple sclerosis. At present, there are no data available on its use in breastfeeding mothers and its transfer in human milk.
Objective:
We present a case of a lactating mother who donated her milk samples to study the transfer of cladribine following a 20-mg oral dose.
Methods:
Analysis was done using liquid chromatography-mass spectrometry.
Results:
The relative infant dose calculated in this study was 3.06%.
Conclusion:
This is the first case report suggesting the transfer of cladribine in human milk in measurable quantities. However, caution should be advised during lactation.
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