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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Defense Against Bacterial Pathogens01:31

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The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
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Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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Bacterial Signaling01:30

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Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
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Burn Injuries01:22

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Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
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Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
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Severe bacterial skin infections.

Sílvio Alencar Marques1, Luciana Patrícia Fernandes Abbade1

  • 1Faculdade de Medicina, Universidade Estadual Paulista, Botucatu, SP, Brazil.

Anais Brasileiros De Dermatologia
|June 9, 2020
PubMed
Summary
This summary is machine-generated.

This review details severe bacterial skin infections like necrotizing fasciitis and Fournier gangrene, emphasizing dermatological manifestations and treatment. It also covers methicillin-resistant Staphylococcus aureus (MRSA) skin infections, including abscesses.

Keywords:
Bacterial infectionsEcthymaFasciitis, necrotizingFournier gangreneFurunculosisMethicillin-resistant Staphylococcus aureus

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Area of Science:

  • Dermatology
  • Infectious Diseases
  • Bacteriology

Background:

  • Severe bacterial infections often present with initial dermatological lesions, requiring prompt dermatological evaluation.
  • Necrotizing skin conditions such as necrotizing fasciitis, Fournier gangrene, and ecthyma gangrenosum are increasingly recognized.
  • Infections caused by methicillin-resistant Staphylococcus aureus (MRSA), including abscesses, furuncles, and carbuncles, are a growing public health concern.

Purpose of the Study:

  • To review severe bacterial diseases with dermatological manifestations, focusing on those with skin necrosis.
  • To individualize the discussion of necrotizing fasciitis, Fournier gangrene, and ecthyma gangrenosum, differentiating them from generic 'necrotizing soft tissue infections'.
  • To include the epidemiology, clinical presentation, diagnosis, and treatment of MRSA skin infections.

Main Methods:

  • Literature review focusing on severe bacterial skin infections.
  • Analysis of epidemiological data, clinical dermatological findings, diagnostic methods, and treatment strategies.
  • Specific attention to necrotizing infections and MRSA-related cutaneous conditions.

Main Results:

  • Detailed descriptions of necrotizing fasciitis, Fournier gangrene, and ecthyma gangrenosum, highlighting their necrotic evolution.
  • Inclusion of MRSA infections (abscesses, furuncles, carbuncles) and their specific etiologies.
  • Comprehensive overview of diagnostic approaches and therapeutic interventions for each condition.

Conclusions:

  • Accurate diagnosis and timely management of these severe bacterial skin infections are crucial.
  • Dermatologists play a key role in the early identification and treatment of these potentially life-threatening conditions.
  • Understanding the specific characteristics of necrotizing infections and MRSA is essential for effective patient care.