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Updated: Dec 19, 2025

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

Can coffee combat caries? An in vitro study.

Divyasri Godavarthy¹, Rashmi Naik², Praveen Kumar Gali³

¹Department of Oral Pathology, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India.

Journal of Oral and Maxillofacial Pathology : JOMFP

|June 9, 2020

Summary

Coffee demonstrates significant anticariogenic properties against Streptococcus mutans, a key bacteria in dental caries. However, its effectiveness diminishes when combined with milk and sugar.

Keywords:

Anticariogenic Streptococcus mutans caries coffee

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Area of Science:

Oral microbiology
Dental research
Natural product chemistry

Background:

Dental caries is a complex disease influenced by oral microflora, diet, and environmental factors.
Streptococcus mutans is a primary bacterial agent in dental caries initiation and progression.
Natural products are increasingly explored for disease prevention, with coffee showing potential anticariogenic properties.

Purpose of the Study:

To evaluate the anticariogenic efficacy of coffee against Streptococcus mutans.
To investigate the impact of coffee formulations on S. mutans activity.

Main Methods:

Saliva samples were collected from 120 healthy individuals aged 18-25, divided into carious and non-carious groups.
Streptococcus mutans was isolated and cultured from saliva samples.
The inhibitory activity of various coffee formulations against S. mutans was assessed.

Main Results:

Coffee, when used alone, exhibited the highest antibacterial activity against S. mutans.
The anticaries activity of coffee was significantly reduced when mixed with milk and sugar (P < 0.01).

Conclusions:

Coffee possesses demonstrable anticariogenic activity against Streptococcus mutans.
Formulations of coffee, particularly those including milk and sugar, may reduce its efficacy in preventing dental caries.