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Updated: Dec 19, 2025

Fluorescence In Situ Hybridization on DNA Halo Preparations to Reveal Whole Chromosomes, Telomeres and Gene Loci
Published on: March 4, 2021
Pink bodies with halo
Sushruth Nayak1, Asha Karadwal1, Amit Aggarwal2
1Department of Oral Pathology, MM College of Dental Sciences and Research, Mullana (Deemed to be University), Ambala, Haryana, India.
Abstract:
The presence of eosinophilic Toto bodies in oral lesions could be found in a variety of situations and sometime may present a challenge to the pathologist. We present three case reports where the oral biopsy was taken from the gingival region of a 30-year-old female, a 32-year-old male patient and another from the buccal mucosa of a 67-year-old male patient. Histopathologically, the three cases were finally diagnosed as pyogenic granuloma and moderately differentiated squamous cell carcinoma with the presence of clusters of Toto bodies in the upper spinous layer of stratified squamous epithelium.
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