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Galectin-1 expression in oral squamous cell carcinoma: An immunohistochemical study
Vaibhavi Salunkhe1, Aarti Mahajan1, Nilima Prakash1
1Department of Oral and Maxillofacial Pathology, MGV's K.B.H. Dental College and Hospital, Nashik, Maharashtra, India.
Journal of Oral and Maxillofacial Pathology : JOMFP
|June 9, 2020
Summary
Galectin-1 (Gal-1) expression is elevated in advanced oral squamous cell carcinoma (OSCC) stages and histological grades, indicating its role in cancer progression and as a potential prognostic marker.
Area of Science:
- Oncology
- Cancer Biology
- Head and Neck Cancers
Background:
- Oral squamous cell carcinoma (OSCC) presents significant mortality and morbidity due to local invasiveness and metastasis.
- Galectin-1 (Gal-1) is implicated in regulating tumor growth, angiogenesis, cell adhesion, and migration.
Purpose of the Study:
- To investigate the expression levels of Galectin-1 (Gal-1) in various clinical stages and histological grades of OSCC.
- To assess the correlation between Gal-1 expression and OSCC progression.
Main Methods:
- Immunohistochemical staining using mouse monoclonal antibodies against Gal-1 was performed on 40 OSCC tissue samples.
- Samples included well-, moderately, and poorly differentiated carcinomas.
- Statistical analysis utilized the Mann-Whitney U-test and Kruskal-Wallis ANOVA test.
Main Results:
- Gal-1 expression was significantly higher in advanced stages of OSCC.
- A statistically significant increase in Gal-1 immunoexpression was observed with advancing histological grades of OSCC.
Conclusions:
- Galectin-1 (Gal-1) expression correlates with the progression of oral squamous cell carcinoma.
- Gal-1 demonstrates potential as a prognostic marker for OSCC invasion and metastasis.
