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Updated: Dec 19, 2025

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity
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Severe Demyelinating Neuropathy in an Advanced Melanoma Patient Treated with Nivolumab plus Ipilimumab Combined

Yumi Kambayashi1, Taku Fujimura1, Hiroshi Kuroda2

  • 1Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Case Reports in Oncology
|June 9, 2020
PubMed

Immune checkpoint inhibitors (ICIs) significantly prolong survival in patients with metastatic melanoma but can lead to serious immune-related adverse events. In this report, we described a case of atypical neuropathy caused by nivolumab plus ipilimumab combination therapy before primary tumor resection. In our case, not only demyelinating neuropathy, but also muscle weakness and unilateral facial nerve palsy developed and manifested as severe and diverse symptoms. Moreover, unlike spontaneously developing demyelinating peripheral neuropathy, the present case suggested the therapeutic effects of high-dose methylprednisolone monotherapy for the treatment of ICIs-induced immune-related demyelinating peripheral neuropathy.

Keywords:
Advanced melanomaDemyelinating peripheral neuropathyHigh-dose methylprednisolone monotherapyImmune-related adverse eventNivolumab plus ipilimumab combined therapy

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