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Updated: Dec 19, 2025
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Regressive melanoma in a female patient: A case report
Florica Sandru1,2, Carmen-Cristina Draghici2, Teodora Predescu3
1'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Abstract:
Regressive melanoma is a phenomenon characterized by partial or complete replacement of cutaneous melanoma by fibrotic structures as a result of local host immune response. The dermoscopic features include 'scar-like' depigmentation that can be described as hypopigmented to pigmented macules, pink macules, linear-irregular vessels, globular vessel pattern, hyperpigmented macular remnants, blue gray 'peppered' papular remnants and white transverse bands. Fully regressive melanoma is very rare, and, in majority of cases, the tumor is associated with metastases, so the prognosis is very poor due to this fact. Regressive melanomas are rare since it represents an advance stage of melanoma evolution. Their treatment requires a collaboration between the dermatologist and the oncologist in order to improve the quality of life of the patient and also the survival rate.
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