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In light-sensitive drug delivery system nanoparticles mediate oxidative stress
1Yangtze Normal University, College of Modern Agriculture and Bioengineering Chongqing, China.
American Journal of Translational Research
|June 9, 2020
Summary
Nanoparticles in drug delivery impact cellular redox balance by regulating heme oxygenase-1 (HO-1) and reactive oxygen species (ROS). Further research is needed to understand these biomedical effects.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cellular Biology
Background:
- Nanoparticles are increasingly used in light-sensitive drug delivery systems.
- Limited research exists on the biomedical effects of nanoparticles, specifically their impact on heme oxygenase-1 (HO-1) expression and reactive oxygen species (ROS) generation.
- These factors are crucial for cellular redox reactions.
Purpose of the Study:
- To review the mechanisms of drug delivery using organic (PLGA, PEG) and inorganic (Au, ZnO, SiO2, TiO2) nanoparticles.
- To explore the potential involvement of the Nrf2/Bach1 pathway in HO-1 regulation.
- To investigate how photon quantum effects influence ROS generation.
Main Methods:
- Literature review.
- Analysis of high-throughput sequencing databases.
Main Results:
- Organic and inorganic nanoparticles are utilized for drug delivery.
- The Nrf2/Bach1 pathway may regulate HO-1 expression.
- Photon quantum effects can alter ROS generation.
- Nanoparticles can influence disease pathogenesis, such as atopic dermatitis.
Conclusions:
- The biomedical effects of nanoparticles are complex and multifaceted.
- The interplay between HO-1 and ROS generation by nanoparticles requires further investigation.
- Understanding these mechanisms is essential for safe and effective nanoparticle-based therapies.
